Chemotherapy induces genomic instability in oral mucosal cells of women with breast cancer
Abstract
Methods: Genomic instability was determined in oral mucosal cells of 31 women diagnosed with breast cancer before and after chemotherapy with alkylating agents’ presence. MSI was assessed by a panel with five different microsatellite regions.
Results: We observed that 77.41% of patients had any genetic alteration in the oral mucosal cells, with a higher number of MSI events by 32.58% compared to LOH events by 24.97%, mainly in the FMR2 (16.29 %) and BAT 26 (13.04%). The control group did not show genomic instability in oral mucosal cells.
Conclusions: The oral mucosal cells are susceptible to genomic instability when exposed to chemotherapy regimens containing alkylating agents which allows us a new approach to chemotherapy regimens and their implications and propose a new biological matrix for assessing such adverse effects.
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PDFDOI: https://doi.org/10.5430/jst.v2n2p10
Journal of Solid Tumors
ISSN 1925-4067(Print) ISSN 1925-4075(Online)
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