P53 mutation compared with Ki67 marker in metastasis of breast cancer in western Iran

Abstract

Objective: To investigate and compare the prognostic value of P53 and Ki67 markers with age and metastasis and survival in patients with breast cancer in Kermanshah, western Iran.

Methods: In our study on 116 patients with breast cancer that all of them were women and kind of pathology was invasive ductal carcinoma and patients had Her2 positive. The expression of ki67 marker and p53 genes were determined by immunohistochemistry. Statistical analysis was performed with SPSS version IBM 19 and Disease free survival was calculated using the Kaplan-Meier method and log-rank test. Patients were followed up to 5 years.

Results: The age mean of patients was 46.5±10.75.Of 116 patients, 23 patients (19.8%) had breast cancer with metastasis and 93(80.2%) without metastasis. expression of P53 (50%) in 58 patients was positive and 58(50%) was negative. there is a statistically significant relationship between the p53 and metastasis (P<0.05), but no for Ki67. The over expression of p53 protein and Ki67 had no significant relationship with survival rate (P>0.05).

Conclusions: The results showed that the Ki67 marker and P53 protein are important factors in the breast cancer patients with emphasis on therapeutic agents.